Twin to Twin Transfusion Syndrome

Two cords tangledTwin to twin transfusion syndrome (TTTS) is a random abnormality of a monochorionic placenta that causes one identical twin to receive less than normal amounts of blood supply during pregnancy while the other receives too much. The babies share blood vessels in their placenta that cause an imbalance of blood flow and nutrients between them.

There are degrees to the severity of the syndrome, but it is always life-threatening due to the fact that it can worsen at anytime during pregnancy. Below is a summary of the difference between dizygotic (fraternal) and monozygotic (identical) twin pregnancies. TTTS can only happen with monozygotic twins, or as a pair in a higher multiple pregnancy, that share a single monochorionic placenta.

NOTE: The following information is provided for your information only and does not necessarily reflect each person’s individual situation. If you have any concerns whatsoever about your pregnancy, please consult your physician immediately.

There are two types of twins:

two eggs meet up with two sperm. These babies are technically siblings who happen to have been born at the same time. They are commonly known as “fraternal”. They always have one placenta each and are called dichorionic (DC).

one egg meets up with one sperm. These babies are always the same gender and are commonly known as “identical”. MZ pregnancies can experience high complication rates, particularly if the twinning process occurs more than 4 days from fertilization resulting in a single monochorionic placenta share by two or more babies.

There are two types of monochorionic pregnancies that can be affected by twin to twin transfusion syndrome:


When the embryo randomly splits between 4-8 days after conception, the pregnancy results with two babies each in their own amniotic sac (diamnionic) as well as sharing a placenta (monochorionic). The majority of these pregnancies proceed without complications. However, approximately 15% of the time, the babies will share blood between them disproportionately and warning signs of the syndrome will appear on ultrasound (see warning signs below). The syndrome can occur with two or more babies in a higher multiple birth pregnancy as long as the babies share a single monochorionic placenta.


When the embryo randomly splits between 8-12 days after conception, the pregnancy results with both babies sharing a single placenta (monochorionic) but the babies are in the same amniotic sac (monoamniotic). This type of pregnancy can still result in TTTS but it is more difficult to diagnose with the babies in the same sac. Also, there is a greater concern that the babies’ cords will become entangled. It is estimated that approximately 50% of the babies will pass away from cord entanglement. It is recommended that mothers be hospitalized at 24 weeks for 24 hour monitoring of the babies until they are born.

One of the warning signs of TTTS shown on ultrasound is a size difference in the babies. One baby, the donor, becomes restricted in growth receiving less then normal blood flow. The donor baby does not urinate very much and has little to no fluid in his or her amniotic sac. Sometimes the baby is referred to as a ‘stuck twin’ or having oligohydramnios. Subsequently, a much larger blood flow goes to the co-multiple, referred to as the recipient twin. Due to the shared, interconnecting veins and arteries in the single placenta, the blood disproportionately flows through the donor twin and collects in the recipient twin, who is unable to efficiently rid his or herself of the extra blood. The recipient baby urinates frequently causing too much amniotic fluid or polyhydramnios. Because of this abnormality in the placenta, both babies’ well-being can be severely compromised.


It is important to understand that one reason babies can become growth restricted is that the babies may share the placenta itself unequally. The donor baby could have less then half of the placenta to nourish it. This is one reason why The Twin to Twin Transfusion Syndrome Foundation advocates weekly ultrasounds from 16 weeks through delivery of the babies. If a baby has a small placental share, and you cannot know prior to birth for sure what the placental share is, the baby will get to a certain gestational week and it will stop growing. The baby will not get enough blood and oxygen from it s share of the placenta to ‘get bigger’ than the size that it is. The rate of growth for the babies is extremely important and is often overlooked. The sharing of the blood from the syndrome also adds to size differences of the babies. TTTS is often combined with an unequal placental sharing.

Some treatment options are available

AGGRESSIVE SERIAL AMNIOCENTECES removal of the excess fluid around the recipient which may need to occur several times;

LASER SURGERY which identifies the connecting blood vessels in the shared monochorionic placenta and cauterizes them with a laser beam. The babies are being separated in the placenta so each will then get their blood supply independently from the other. The scope used is inserted through amniotic cavity of the recipient baby. There are specific criteria that must be met based on ultrasound findings.

BEDREST AND NUTRITION which is explained below and combined with the therapies listed above.

What Can We, as Parents, Do?

  1. Make sure your obstetrician has plenty of high-risk pregnancy experience.
  2. Make sure that your obstetrician uses intensive ultrasound to determine the chorionicity (DC or MC) of the babies as early as possible in the pregnancy. If the babies are like-sexed, you need to know if they share a placenta or each have their own. If they share a placenta, weekly ultrasounds are crucial in the care of your babies and you may have to really fight to have them. Don’t take no for an answer. If the babies are unlike-gender, they must be fraternal twins and cannot have TTTS. Keep asking questions until you are satisfied and understand the answers.
  3. If your babies are monochorionic, take really good care of yourself. One way is to follow advice from Dr. Julian De Lia who pioneered laser surgery almost 20 years ago. He is now recommending adding protein drinks to your diet, such as 3 cans of Boost drinks a day. He feels that TTTS can make mothers malnourished adding to the fluid problem around the recipient babies. Drinking the protein can help get the protein in your blood back to normal. Many women have seen improvements from this. Nutrition is completely overlooked by most doctors. Bedrest is also strongly encouraged along with adding liquid protein. Bedrest is defined as laying horizontally on your left side and getting up to eat, shower, use the bathroom, and go to appointments. Laying on your left side takes pressure off of your cervix and helps increase blood and oxygen to the placenta to help your babies.
  4. Make sure that your cervix is checked weekly. This is also overlooked by many doctors. If your cervix length shortens to 2cm or less, a cerclage or stitching of the cervix can be done up through 25 weeks. This has saved many pregnancies. Laser surgery can still be done after a cerclage only through the 26th week.
  5. If early signs of TTTS appear, or there is a sudden increase in your size, ask for a perinatology appointment immediately. Your feto-maternal medicine specialist will know about the options for treatment. Ask what they think about possible laser treatment and whether this is a possibility for you. Once again, don’t take no for an answer. It is also encouraged by The TTTS Foundation to contact the laser doctors on your own so you get the correct and up-to-date information directly from the doctors who perform the procedure.
  6. Understand a monochorionic placenta and what TTTS is. Understand specifically what is happening to your babies with measurements of their size difference, your fundal height, the biggest pocket of fluid around each baby, where your placenta is located in the uterus, their doppler readings and your cervix. Create a medical plan of action with back-up plans so you can be as prepared as you can for each appointment.

Warning Signs of TTTS

  •  a large-for-dates uterus
  • water in baby(ies) body (heart failure called hydrops)
  • a single placenta
  • same sex babies
  • growth discordance, babies are growing at different rates
  • too much amniotic fluid in one sac and too little in the other
  • being 16-26 weeks pregnant with fundal height of 30 cm or more
  • a doppler reading for the babies which is absent diastolic or reverse flow
  • a cervix which is thinning and shortening to 2cm or less
  • sudden weight gain and/or swelling in the mother’s body

The TTTS Foundation says that without treatment, the death rate for twins who develop TTTS at mid-pregnancy (16 to 26 weeks gestation) may be as high as 80-100, mostly as a result of premature delivery. The later the condition develops in the pregnancy, the better chance the babies have since they could be delivered if signs of distress are present. Your health care professional is the best source of information regarding your personal situation and can discuss fully with you how your situation can be managed. However, remember that the ultimate decisions for your children are yours.

Please also note that TTTS can occur with monozygotic (identical) sets of babies in triplets, quads or quints and not just twins.  If you are pregnant with multiples, you need to know if you are carrying any monozygotic babies and if they have TTTS.


Diamniotic twins: twins who have developed in separate amniotic sacs. They may be either dizygotic or monozygotic.
Dichorionic twins: twins who have developed in separate chorionic sacs. They may be either dizygotic or monozygotic.
Dizygotic twins: twins formed from two separate zygotes.
Fraternal twins: see dizygotic twins
Higher order multiples: triplets, quadruplets, quintuplets or more
Hydropic (hydrops): a condition due to the abnormal accumulation of serous fluid in the tissues or in a body cavity
Identical twins: see monozygotic twins
Monoamniotic twins: twins who have developed in a single amniotic sac. These twins are always monozygotic.
Monochorionic twins: twins who have developed in a single chorionic sac. These twins are always monozygotic.
Monozygotic (monozygous) twins: twins formed from a single zygote.
Oligohydramnios: the presence of too little amniotic fluid around a baby.
Polyhydramnios: the presence of too much amniotic fluid around a baby.
Serous fluid: a thin and watery fluid
Zygote: a fertilized ovum.

Twin to twin transfusion syndrome (TTTS): results from abnormalities of the placenta in monozygous twin pregnancies. TTTS results from blood passing disproportionately (transfusing) from one twin baby to the other through connecting blood vessels within the shared (monochorionic) placenta. (TTTS Foundation)

Written by Lynda P. Haddon, Multiple Birth Educator,

Consultation Sources for this article

  • Elizabeth Bryan, M.D., FRCP, FRCPCH, Founder, Multiple Births Foundation, London, England
  • Mariana Herskovitz, M.D., General Practice, Ottawa, Canada
  • Dr. Geoff Machin, Department of Pathology, Kaiser Medical Center, Oakland, California, USA
  • Mary Slaman-Forsythe, BS. MNO, Founder and President, The Twin to Twin Transfusion Syndrome Foundation, Bay Village, Ohio, USA
  • Julia Watson-Blasioli, R.N., B.Sc.N., Ottawa Hospital, General Campus


  • Multiple Blessings, by Betty Rothbart, 1994
  • Double Duty by Christina Baglivi Tinglof, 1998
  • Twins! Pregnancy, birth and the first year of life, by Connie L. Agnew, Alan H. Kein and Jill Alison Ganon, 1997
  • Twin to Twin Transfusion Syndrome Foundation, literature
  • Dr. Julian E. Delia, Founder and Director of the International Institute for the Treatment of Twin to Twin Transfusion Syndrome, St. Joseph’s Woman’s Hospital, Milwaukee, WI WS:

Other Resources

Losing Multiples

In October 2005, my husband and I were so excited to find out I was pregnant. After two previous miscarriages, the doctor sent me for my first ultrasound at seven weeks. To our surprise we found out that we were expecting twins. This wasn’t too much of a shock since we already have four year old fraternal twins girls and were told our chances of having twins again were quite high.

My doctor then sent us for another ultrasound and we got another shock. I was twelve weeks pregnant and the radiologist started to do the ultrasound and couldn’t believe what she was seeing. She had told us that she had never seen this before and was in total shock. I was scared at this point because of our previous miscarriages so I asked if everything was okay with the two babies. She said they were fine but there are actually three babies. We were having triplets!

Baby B had been hiding on the first ultrasound. We found out that Baby A and Baby B were in the same sack, which meant they were identical and Baby C was in its own sack which meant that he/she was fraternal. We were so excited. We always wanted a big family but couldn’t believe it was happening with just two pregnancies and no fertility drugs. When I went to see my doctor, he said I would be going for ultrasounds every two to four weeks because of the high risk factor with carrying triplets.

At sixteen weeks we went for another ultrasound and everything seemed to being okay. Baby A was slightly bigger than Baby B so they were a little concerned about (Twin-to-Twin Transfusion Syndrome) TTTS. Baby C was right on schedule. They told us they would watch this [TTTS] and there were procedures they could do if need be. The doctor did not seem too worried about it and said to come back for another ultrasound in four weeks.

At twenty weeks we went for another ultrasound and had another shock. The doctor came in, put his hand on my knee and said there is no easy way to tell you this but Baby A and Baby B had passed away but Baby C was doing fine. They figured it had just happened within the last three to five days and there was really nothing they could have done. They told us that Baby A was taking from Baby B which is called TTTS. It was so hard to believe that this was really happening. On the ultrasound they looked fine, they were two fully formed little babies but their little hearts just stopped working. We were devastated. It was so hard first we were told twins, then triplets and now we only have one. We know we have to stay positive for the little guy that is staying so strong for us but it is so difficult after losing multiples already. The doctors told us the Baby C is oblivious to what was going on and expect him/her to go to full term or close to it.

I didn’t want to know what I was having when I found out I was having triplets but after finding out this terrible news I needed to hear something positive so we found out that Baby C is a boy. We didn’t care whether it was a boy or a girl, we just needed some happy news. I am now 26 weeks pregnant and Baby C is still doing well. They were worried about me going into pre term labor but so far so good. I have days where I don’t want to get out of bed but have to be strong for my two little girls and my beautiful baby growing inside. We have good days and bad days but reading other peoples stories have really helped me to stay strong for my little boy who is truly a blessing. If we had not found out we were having triplets and just twins we would not have a baby right now that is developing so well and doing great. God has given us five precious gifts.

My two angels are in heaven now looking down watching over us. My two four year old girls are amazing and cannot wait to meet their new little brother, whom should be arriving in June 2006.

Rhonda (Edmonton, AB)

Our Christmas Miracles!

I went for my routine scan and it was to be an internal one. The doctor could see something other than a baby’s heartbeat. It turns out it was another baby’s heartbeat. We were having TWINS!

I was only 6 weeks along and already they could see that they were identical twins, both sharing the same placenta, but separate amniotic sacs. I was shocked. My partner wasn’t because he has them in every generation of his family.

I was transferred from the anti-natal unit to the neonatal medicine unit where I was scanned every fortnight [2 weeks]. Then at 13 weeks, I went for my routine scan and it was noticed that the babies had Twin-to-Twin-Transfusion syndrome (T.T.T.S.). It was quickly becoming an issue for the babies. My counsellor told me what to expect. My case showed that there was a 10% chance of survival of one baby and barely any of two surviving. There was also an 85% chance of brain damage or celebral palsy to one or both babies. All we did was cry. She told us we should think about ending the pregnancy as it takes a very strong person to look after one disabled child never mind two, our working days would be over and they would need 24/7 care, by both me and my partner. I very nearly gave up but my partner gave me hope, so on we went with our pregnancy.

We discussed other options such as laser surgery and amnio-reduction. My placenta was lying across the front of my stomach so laser surgery was out of the question. The placenta in such a position worsened our case as laser surgery has a better chance of survival. Amnio-reduction was the next best thing so we chose that option.

Amniotic fluid was drained from around the bigger baby’s sac to even out the fluid, but after a few weeks the fluid crept up again. We had a foetal doppler scan and discovered hydrops had developed on one of their hearts, which can cause heart failure. We were then sent to a consult in women’s hospital in Birmingham. I went on to have another amnio-reduction in Birmingham. This time they took off quite a lot of fluid, so I had to stay overnight and the hope was that I would get to about 32 weeks to give the babies a better chance.

Back in my local hospital, I was 27 weeks and there was a reverse endystolic flow in one of the babies’ cords. I was advised to burn one the babies’ cords to give the other baby a stronger chance although there was still not a definite chance for the survival of either of them. Further, due to possible strokes because of the two different blood pressures in the cords, there was a chance we could lose them both at birth. On yet another routine scan at 30 weeks, it was discovered that the reverse flow was back and much worse. I was kept in over night and received steroid injections to help develop the babies’ lungs. I was scanned on the 15th December 2004, 10 weeks before my due date and we were told the worst and the best thing: our babies were coming into the world the next day.

Thursday, 16th December 2004, I went down to theatre [delivery room] and at 13.07pm Twin 1 (BRANDON) was born weighing 3lb 2oz. Then three minutes later Twin 2 (BAILEY) was born weighing 3lb 15oz. They were whisked off to S.C.B.U. [equivalent to North American NICU (Neonatal Intensive Care Unit)].

I didn’t get to see them until the next day. It was the best day of our lives; we had two healthy boys. We are so very lucky and give special thanks to all the staff who looked after us and our two little miracles right through the pregnancy. They were in S.C.BU. For 6 weeks. We were constantly there feeding and changing. They finally came home beginning of February 2005.

We were so very lucky and they are our Christmas miracles. We thank everybody involved in bringing these two bundles of joy into our lives. They are now 9 months old and an absolute joy to have. We just can’t believe how lucky we are. Thank you. We hope this story helps other people in the same situation as us.

Clare and John, United Kingdom, Proud parents of Bailey and Brandon.